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The melanocytomas that arise within this pathway harbor secondary mutations that activate protein kinase A ( PRKAR1A - inactivated melanocytoma) or the beta-catenin pathway (deep penetrating or beta-catenin-activated melanocytoma) or perturb the epigenetic state of the genome ( BAP1 -inactivated melanocytoma)
Additionally, there is a boxed warning regarding thyroid C-cell tumors observed in rodent studies
Allergic reactions: Although rare, allergic reactions to tirzepatide are possible
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